Breast Cancer Organizations
This finding by a team of biologists from Boston University is the first to associate the choline intake during pregnancy to breast cancer. It is the first to identify possible related to the hill genetic changes that affect the survival of breast cancer rates.
"We've known for a long While some agents taken by pregnant women, as diethylstibesterol have adverse effects Editor of the implications for their daughters, "said Gerald Weissmann, MD, Editor in Chief of The FASEB Journal. "But there is a positive side. The new science of epigenetics has produced a breakthrough. For the first time, we learned that we may be able to prevent breast cancer as soon as the pregnancy of a mother. "
The researchers made the discovery in rats by studying women whose mothers were fed with different amounts of choline during pregnancy. Different groups of pregnant rats received diets containing standard quantities of the hill, Hill is not at all, or the extra hill. Then the researchers treated female offspring with a chemical that causes mammary gland cancer (cancer of breast). Although animals in all groups developed breast cancer, the daughters of mothers who received extra choline during pregnancy had growing tumors slow, while the daughters of mothers who did not have the hill during pregnancy had rapidly growing tumors.
"Our study provides support Additional to the idea that the hill is an important nutrient that must be taken into account when developing dietary guidelines, "said Krzysztof Blusztajn, Ph.D., Professor of Pathology, Boston University and principal investigator of the study. "We hope this will be possible to develop nutrition guidelines for pregnant women ensure the good health of their children into old age. "
The researchers also found multiple genetic and molecular alterations of the tumors of rats that correlated with survival results. For example, the slow-growing tumors in rats had a genetic pattern similar to those observed breast cancers in women who are considered to have a good prognosis. The fast-growing tumors in mice had a similar pattern of genetic changes to those observed in women with more aggressive disease. The researchers also found evidence that these genetic changes that may result from the way it affects the hill DNA modifications within the mammary gland of the gland of fetuses as they develop in utero.
The National Cancer Institute estimates there will be more than 184,000 new cases of breast cancer in 2008 and more than 40,000 deaths. Treatments for women suffering from breast cancer hormone therapy range for surgery. Adapted from materials provided by the Federation of Societies American Experimental Biology, via EurekAlert!, A service of AAAS. ScienceDaily
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